Genetics

Zebrafish epigenetics

A change in phenotype without a change in genotype

 


Ferenc’s group studies transcription regulation in vertebrate embryo development. Their research focuses on the DNA sequence codes, which define promoter-enhancer interactions. They apply comparative/functional genomic analysis of cis-regulatory elements and develop high throughput approaches to study transcriptional regulators in the zebrafish embryo model system. They study the epigenetic mechanisms, which regulate genome activation and use epigenomics tools to characterize early development. They exploit the advantages of zebrafish in search for non-coding mutations causing human disease and study the in vivo roles of orthologs of human genes that have been associated with disease causing mutations. His group currently consists of 6 post docs and 3 PhD Students. Their research is funded by programmes of EU Horizon 2020, BBSRC, MRC, Human Frontier Science Program and a Wellcome Trust Investigator award.