Driven by the desire to use sustainable and efficient synthetic chemical technologies, the NEURAM Chemistry team are developing new routes to labelled nucleotide analogues. These analogues consist of a molecular framework that binds strongly with RNA and DNA, as well as including imaging motifs that are under-exploited. Through collaboration with the leading scientists and companies of the NEURAM team our chemists will be able to: synthesise new monomers, incorporate them into oligomeric structures and deploy them as imaging tools to reveal new understanding of neuroscience at a genetic level.