THE DESIGN OF NEW METHODS FOR THE CONSTRUCTION OF COMPLEX MOLECULES
The synthesis of small molecule analogues of nucleotides with unique imaging modality. These analogues are subsequently transformed into bespoke oligomeric sequences for use in visualising nucleic events. Towards this goal, the synthesis of alkyne-tagged building blocks is being developed and elaborated in our laboratories.
Driven by the desire to use sustainable and efficient synthetic chemical technologies, the NEURAM Chemistry team are developing new routes to labelled nucleotide analogues. These analogues consist of a molecular framework that binds strongly with RNA and DNA, as well as including imaging motifs that are under-exploited. Through collaboration with the leading scientists and companies of the NEURAM team our chemists will be able to: synthesise new monomers, incorporate them into oligomeric structures and deploy them as imaging tools to reveal new understanding of neuroscience at a genetic level.